OBJECTIVE To determine the difference in the success rate for two types of oral installed mini-implants (OMIs): one type of initially installed OMI and a new implant of the same type that is reinstalled. MATERIALS AND METHODS The subjects consisted of 58 patients (19 male, 39 female; mean age = 21.78 +/- 5.85 years) who had received at least one OMI (self-drilling type, conical shape with 2.0...

The mitochondrial protease OMI (also known as HtrA2) has been implicated in Parkinson's Disease (PD) and deletion or protease domain point mutations have shown profound neuropathologies in mice. A beneficial role by OMI, in preserving cell viability, is assumed to occur via the avoidance of dysfunctional protein turnover. However relatively few substrates for mitochondrial Omi are known. Here w...

Recently, a mutation in the mitochondrial protease Omi/HtrA2, G399S, was found in sporadic Parkinson's disease (PD) patients, leading to the designation of Omi/HtrA2 as PD locus 13 (PARK13). G399S reportedly results in reduced Omi protease activity. In vitro studies have suggested that Omi/HtrA2 acts downstream of PINK1, mutations in which mediate recessive forms of PD. We, as well as other, ha...

Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in vivo is unknown. We aim to observe the effects of mitochondria-specific, not cytoplasmic, Omi/HtrA2 ...

[1] This paper is an overview of the validation of the total column ozone data products from the Ozone Monitoring Instrument (OMI) on board the NASA EOS-Aura satellite. OMI is an imaging UV/visible spectrometer that maps global ozone on a daily basis. There are two ozone products from OMI, one derived using the traditional TOMS retrieval algorithm and another derived using a Differential Optica...

OBJECTIVE Orthodontic mini-implants (OMI) generate various horizontal and vertical force vectors and moments according to their insertion positions. This study aimed to help select ideal biomechanics during maxillary incisor retraction by varying the length in the anterior retraction hook (ARH) and OMI position. METHODS Two extraction models were constructed to analyze the three-dimentional f...

The serine protease HtrA2/Omi is released from the mitochondria into the cytosol following apoptosis stimuli, leading to the programmed cell death in caspase-dependent and -independent manners. The function of HtrA2/Omi closely relates to its protease activity, which is required for cleavage of its substrate such as the members of the X-linked inhibitor of apoptotic protein family. However, the...

HtrA2/Omi is a mitochondrial serine protease that is released into the cytosol and promotes apoptotic processes by binding to several members of the inhibitors of apoptosis protein family. HtrA2/Omi knockout mice show a parkinsonian phenotype, and mutations in the gene encoding HtrA2/Omi have been identified as susceptibility factors for Parkinson disease (PD). These results suggest that HtrA2/...

The serine protease HtrA2/Omi, a regulator of apoptosis, is localized in mitochondria and is released into the cytosol after apoptotic stimuli. Previous studies demonstrate that Omi/HtrA2 is associated with a variety of malignancies. In the present study, we analyzed the expression of Omi/HtrA2 in 52 epithelial ovarian carcinoma (EOC) tissues and paired corresponding adjacent non-tumor tissues ...